Cameron made her film debut in fantasy comedy The Mask opposite Jim Carrey in 1994. She had previously been a model with the Elite agency.
Following Cameron's film debut in The Mask, major roles followed in In Her Shoes, Feeling Minnesota and this film A Life Less Ordinary, the Danny Boyle directed road movie co-starring Ewan MacGregor.
Cameron cemented her global appeal with the hit comedy There's Something About Mary, co-starring with Ben Stiller in 1998.
Cameron voiced the character of Princess Fiona in the hit animated movie Shrek in 2007 which grossed £798 worldwide.
Cameron dated fellow actor Matt Dillon briefly in the 90s.
Cameron dated Justin Timberlake for three years between 2003-2006.